Neurodevelopmental Outcome of Survivors of Neonatal Candidiasis: A Systematic Review
CPS ePoster Library. Barton M. 06/25/15; 99119; 56
Dr. Michelle Barton
Dr. Michelle Barton
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Abstract
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Neurodevelopmental Outcomes in Survivors of Neonatal Candidiasis: A Systematic Review
Forbes J, Barton M.
Background
Neonatal Candidiasis (NC) is a leading cause of infectious disease-related death in very low birth weight (VLBW) infants. It is associated with high mortality and morbidity. Research over the last decade has focused on the long-term outcome of survivors of this disease. There is a need to review data from these studies to quantify the long-term impact of this disease.
Objective
To conduct a systematic review with the aim of doing a meta-analysis of the available data from cohort studies.
Methodology
We conducted a search of MEDLINE (1946-May 2015) and EMBASE (1974-May2015) using the OVID search engine. Combinations of MeSH and text phrases/words used included: candida, Candida albicans, Candida glabrata, Candida tropicalis, candidiasis, cutaneous candidiasis, invasive candidiasis, infant, newborn, LBW, VLBW, extremely premature, premature, cerebral palsy, blindness, deafness, child development and developmental disabilities. Observational studies in English conducted on VLBW infants with invasive candidiasis were selected if neurodevelopmental impairment (NDI) was an outcome measured. Articles were reviewed by two independent reviewers. Data on study design and year of publication, sample size and estimate of effect were collected. Studies were assessed for study quality. Mantel Haenszel method (fixed effects) was used to calculate summary estimate of odds ratio.
Results
Seven observational studies were selected of which one was case control and the other six were cohort studies. Six studies were included in the metaanalysis of NDI outcome and 7 studies in NDI and death. NC was associated NDI (pooled OR =2.38 (1.89-2.97) and with NDI and death (pooled OR=3.68 (3.08-4.40) . Subcomponents of NDI also were separately significantly associated with NC in subgroup analysis. Sensitivity analysis confirmed that findings were robust.
Conclusion:
Neonatal candidiasis is associated with a significant risk of neurodevelopmental impairment. Death and NDI were also more significantly more likely following NC. Outcomes following meningitis and UTI were not routinely reported resulting in too few studies for subgroup analysis. These findings establish the need for effective preventive strategies.
Neurodevelopmental Outcomes in Survivors of Neonatal Candidiasis: A Systematic Review
Forbes J, Barton M.
Background
Neonatal Candidiasis (NC) is a leading cause of infectious disease-related death in very low birth weight (VLBW) infants. It is associated with high mortality and morbidity. Research over the last decade has focused on the long-term outcome of survivors of this disease. There is a need to review data from these studies to quantify the long-term impact of this disease.
Objective
To conduct a systematic review with the aim of doing a meta-analysis of the available data from cohort studies.
Methodology
We conducted a search of MEDLINE (1946-May 2015) and EMBASE (1974-May2015) using the OVID search engine. Combinations of MeSH and text phrases/words used included: candida, Candida albicans, Candida glabrata, Candida tropicalis, candidiasis, cutaneous candidiasis, invasive candidiasis, infant, newborn, LBW, VLBW, extremely premature, premature, cerebral palsy, blindness, deafness, child development and developmental disabilities. Observational studies in English conducted on VLBW infants with invasive candidiasis were selected if neurodevelopmental impairment (NDI) was an outcome measured. Articles were reviewed by two independent reviewers. Data on study design and year of publication, sample size and estimate of effect were collected. Studies were assessed for study quality. Mantel Haenszel method (fixed effects) was used to calculate summary estimate of odds ratio.
Results
Seven observational studies were selected of which one was case control and the other six were cohort studies. Six studies were included in the metaanalysis of NDI outcome and 7 studies in NDI and death. NC was associated NDI (pooled OR =2.38 (1.89-2.97) and with NDI and death (pooled OR=3.68 (3.08-4.40) . Subcomponents of NDI also were separately significantly associated with NC in subgroup analysis. Sensitivity analysis confirmed that findings were robust.
Conclusion:
Neonatal candidiasis is associated with a significant risk of neurodevelopmental impairment. Death and NDI were also more significantly more likely following NC. Outcomes following meningitis and UTI were not routinely reported resulting in too few studies for subgroup analysis. These findings establish the need for effective preventive strategies.
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